Biocompatibility is regarded as a material's quality of being compatible with the biological environment, i.e. the material’s ability to interact with living tissues by causing no, or very little biological reactions. A dental material is considered to be “biocompatible“ if its properties and function match the biological environment of the body and do not cause any unwanted reactions.

Toxicon Testing Laboratory:
Based on the criteria of the protocol, IPS e.max lithium disilicate, is considered non-cytotoxic and meets the requirements of the Agar Diffusion Test, ISO 10993-5 guidelines.

Dr. John Wataha Report:
A study by Dr. John Wataha concluded that the biocompatibility of IPS e.max lithium disilicate was greater than or equal to many commonly used dental alloys and dental restoratives (composites and glass ionomers).